Very often penile cancer occurs histologically as a squamous cell carcinoma. Its treatment is based on radiation therapy and surgery and depends on the stage of the tumor, age of patient, and anatomy and pathology of the lymph system of the male genitalia. In evaluation of 69 cases, the problems of therapy and prognosis are discussed. Preventive circumcision for the purpose of facilitating genital hygiene is reputed to be the operative prophylaxis.